The IonPix camera
We have recently brought to market the IonPix camera, a retrofit imaging detector for ToF based mass spectrometry systems. The detector is based on a 512×512 active pixel array, operating in parallel acquisition mode. Each pixel has its own dedicated electronics and registers individual ion arrival times digitally. This enables measurements without electronic noise, increases sensitivity and extends mass range. In addition the IonPix camera provides fast mass spectrometric imaging capabilities with high spatial resolution. The detector turns a single ToF-MS system into more than a quarter million parallel ToF-MS systems. The detector can be retrofitted to any standard 4” DN100CF flange.
Compatible with TOF MS systems
Omics2Image offers the IonPix camera as OEM and retrofit model.
True MS Imaging
The IonPix camera obtains large area mass resolved images (square millimeter) with submicrometer resolution of tissue at very high speeds. The figure shows a representation of such a dataset. This data was acquired within 6 hours, a comparable image would take 95 days with existing imaging Mass Spectrometry methods. The most recent version of our camera acquires the same data within half an hour, effectively 4000 times faster compared to existing methods.
Shane Ellis, PhD, presents results of the IonPix camera on high mass intact protein detection at ASMS on June 10th, 2013. The IonPix camera superior dynamic range allows resolving triple charged antibody lgG3+, which is barely visible above the noise in the spectrum of conventional detectors. The IonPix camera even detects low concentrations of modified lgG, which conventional detectors cannot resolve as it is hidden in their inherent noise level.
|MCP gain threshold||4*105||4*106||4*106|
|Time resolution||10 ns||2 ns||138 ps|
|TOF range (single experiment)||118 μs*||200 μs||60 μs|
|Detection of ions arriving at the same time||yes||yes||no|
|Electronic noise free||yes||no||no|
|Applied Biosystems/MDS SciexMALDI ToF/ToF 4800MALDI ToF/ToF 4700
Biflex and Reflex series
Axima CFR / CFR plus